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KMID : 0613820110210091274
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Journal of Life Science
2011 Volume.21 No. 9 p.1274 ~ p.1280
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Improvement Effect of Cordycepin-Enriched Cordyceps militaris JLM 0636 Powder against Orotic Acid-Induced Fatty Liver in Rats
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Cha Jae-Young
Ahn Hee-Young
Heo Su-Jin
Park Sang-Hyun
Jeong Yong-Kee
Cho Young-Su
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Abstract
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The concentration of cordycepin produced by crossbred Cordyceps militaris JLM 0636 (CMα) was 7.42 mg/g dry weight, which was 7-fold higher than that of C. militaris (CM). However, cordycepin was not detected in Paecilomyces japonica (PJ). The improvement effects of CMα, CM and PJ on orotic acid (OA)-induced fatty liver in male Sprague-Dawley rats was investigated. Rats were randomly divided into five groups (n=6) based on five dietary categories: normal (N), OA control (C), OA plus 3% (w/w) PJ (PJ), OA plus 3% CM (CM), and OA plus 3% CMα (CMα). OA treatment induced the retardation of body weight gain and enlargement of the liver. The concentration of hepatic triglyceride was markedly increased by OA-feeding, whereas this rise was significantly reduced by simultaneous feeding of OA, PJ, CM, and CMα, and this phenomenon was more pronounced by cordycepin-enriched CMα. The contents of total lipid, triglyceride, and free fatty acid in the serum were significantly or slightly lower in the OA control group than those of the N group, but there were no significant differences among the OA treatment groups. The hepatocytes in the OA-induced fatty liver contained numerous large lipid droplets, but PJ, CM, and CMα feeding prevented the OA-induced lipid droplet accumulation in the hepatocytes. This effect was more pronounced in cordycepin-enriched CMα than in PJ or CM in OA treatment rats. Accordingly, cordycepin-enriched CMα could be an ideal candidate material as a dietary supplement in healthy functional foods to improve the effects of fatty liver.
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KEYWORD
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Cordyceps militaris, Paecilomyces japonica, cordycepin, orotic acid, fatty liver
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